Gregory M. McInnes, PhD

Experience

Education

Publications

1. Cheng-Chieh Hsu, Baohai Shao, Jenny E. Kanter, Yi He, Tomas Vaisar, Joseph L. Witztum, Janet Snell-Bergeon, Gregory McInnes, Shannon Bruse, Omri Gottesman, Adam E. Mullick, Karin E. Bornfeldt. "Apolipoprotein C3 induces inflammasome activation only in its delipidated form." Nature Immunology, 2023.
2. Megan L. Koleske, Gregory McInnes, Julia E. H. Brown, Nathaniel Thomas, Kelly Hutchinson, Michelle Y. Chin, A. Koehl, Michelle R. Arkin, Renata C. Gallagher, Y. Sharon Song, Russ B. Altman, Kathleen M. Giacomini. "Large-scale functional characterization of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency." Proceedings of the National Academy of Sciences, 2022.
3. Gregory McInnes, Russ B. Altman. "Drug Response Pharmacogenetics for 200,000 UK Biobank Participants." Pacific Symposium on Biocomputing, 2021.
4. Gregory McInnes, Sook Wah Yee, Yash Pershad, Russ B. Altman. "Genome-wide association studies in pharmacogenomics." Clinical Pharmacology & Therapeutics, 2021.
5. Gregory McInnes*, Andrew G. Sharo*, Megan L. Koleske*, Julie E. H. Brown*, Matthew Norstad, Aashish N. Adhikari, Sheng Wang, Steven E. Brenner, Jodi Halpern, Barbara A. Koenig, David C. Magnus, Renata C. Gallagher, Kathleen M. Giacomini, Russ B. Altman. "Opportunities and challenges for interpreting rare variation in clinically important genes." American Journal of Human Genetics, 2021.
6. Adam Lavertu, Alison Stribling, Matt White, Gregory McInnes, Russ B. Altman, Rajiv Pramanik, Amit Kaushal. "Covid Fast Fax: A system for real-time triage of Covid-19 case report faxes." medRxiv, 2020.
7. Gregory McInnes, Rachel Dalton, Katrin Sangkuhl, Michelle Whirl-Carrillo, Seung-been Lee, Philip S. Tsao, Andrea Gaedigk, Russ B. Altman, Erica L. Woodahl. "Transfer learning enables prediction of CYP2D6 haplotype function." PLoS Computational Biology, 2020.
8. Christopher DeBoever, Yosuke Tanigawa, Matthew Aguirre, Gregory McInnes, Adam Lavertu, Manuel A. Rivas. "Assessing Digital Phenotyping to Enhance Genetic Studies of Human Diseases." American Journal of Human Genetics, 2020.
9. Gregory McInnes*, Adam Lavertu*, Katrin Sangkuhl, Teri E. Klein, Michelle Whirl-Carrillo, Russ B. Altman. "Pharmacogenetics at Scale: An Analysis of the UK Biobank." Clinical Pharmacology & Therapeutics, 2020.
10. Adam Lavertu*, Gregory McInnes*, Yosuke Tanigawa, Russ B. Altman, Manuel A. Rivas. "LPA and APOE are associated with statin selection in the UK Biobank." bioRxiv, 2020.
11. S. Rensi, Russ B. Altman, Tianyun Liu, Yvonne C. Lo, Gregory McInnes, Andrew Derry. "Homology Modeling of TMPRSS2 Yields Candidate Drugs That May Inhibit Entry of SARS-CoV-2 into Human Cells." ChemRxiv, 2020.
12. Gregory McInnes, Yosuke Tanigawa, Christopher DeBoever, Adam Lavertu, Jonathan E. Olivieri, Marina Aguirre, Manuel A. Rivas. "Global Biobank Engine: enabling genotype-phenotype browsing for biobank summary statistics." Bioinformatics, 2019.
13. Gregory McInnes, Roxana Daneshjou, Panagiotis Katsonis, Olivier Lichtarge, Raj Gopal Srinivasan, Sadhna Rana, Predrag Radivojac, Sean D. Mooney, Kymberleigh A. Pagel, Moses Stamboulian, Yuxiang Jiang, Emidio Capriotti, Yanran Wang, Yana Bromberg, Samuele Bovo, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio, Laura R. Pal, John Moult, Steven E. Brenner, Russ B. Altman. "Predicting venous thromboembolism risk from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges." Human Mutation, 2019.
14. Christopher DeBoever, Yosuke Tanigawa, Malene E. Lindholm, Gregory McInnes, Adam Lavertu, Erik Ingelsson, Christopher S. Chang, Euan A. Ashley, Carlos D. Bustamante, Mark J. Daly, Manuel A. Rivas. "Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study." Nature Communications, 2018.
15. Adam Lavertu, Gregory McInnes, Roxana Daneshjou, Michelle Whirl-Carrillo, Teri E. Klein, Russ B. Altman. "Pharmacogenomics and big genomic data: from lab to clinic and back again." Human Molecular Genetics, 2018.
16. Cuiping Pan*, Gregory McInnes*, Nicole Deflaux, Michael Snyder, Jonathan Bingham, Somalee Datta, Philip S. Tsao. "Cloud-based interactive analytics for terabytes of genomic variants data." Bioinformatics, 2017.

Patents

1. Treatment of CDHR3 Related Diseases and Disorders · 2024 · pending · WO2025222056A1
2. Treatment of COLGALT2 Related Diseases and Disorders · 2024 · pending · WO2025240505A1
3. Treatment of CSPG4 Related Diseases and Disorders · 2024 · pending · WO2025240482A1
4. Treatment of PLOD2 Related Diseases and Disorders · 2024 · pending · WO2025240499A1
5. Treatment of CPN1 Related Diseases and Disorders · 2023 · pending · WO2025137323A1
6. Treatment of FGG Related Hearing Disorders · 2023 · pending · WO2024206673A3
7. Treatment of GPAM Related Diseases and Disorders · 2022 · pending · EP4544052A1
8. Treatment of HGFAC Related Diseases and Disorders · 2022 · pending · WO2023178264A2
9. Treatment of MS4A4E Related Diseases and Disorders · 2022 · pending · EP4540391A2
10. Gene Therapy Treatment of MTRES1 Related Diseases and Disorders · 2022 · pending · WO2024091874A1
11. Treatment of MTRES1 Related Diseases and Disorders · 2022 · pending · MX2025006351A
12. Small Molecule Treatment of MTRES1 Related Diseases and Disorders · 2022 · pending · WO2024091873A3
13. Treatment of SOS2 Related Diseases and Disorders · 2022 · pending · US20250333732A1

Software

1. Gene2Rx for iOS · 2026 — A companion app for Gene2Rx that puts your pharmacogenomics report in your pocket. View your genetic drug-response profile, track medications with PGx awareness, log symptoms and mood, and spot trends over time.
2. Genomisaur · 2026 — A direct-to-consumer genetic analysis platform that transforms existing DNA data into polygenic risk score reports, trait predictions, and family planning insights. No new DNA kit required.
3. Top Set Form Check · 2026 — AI-powered form analysis for barbell lifts. Record a set, get an instant grade with phase-by-phase feedback, coaching cues, and safety flags. Track your technique over time.
4. GreenGauge · 2025 — Lower your scores with data-driven insights. A comprehensive golf performance tracker that identifies patterns, tracks progress, and delivers personalized coaching insights.
5. Nomen · 2025 — A private, on-device memory assistant that helps you capture and recall the details of your life—powered by Apple Intelligence, with all data staying on your device.
6. RateReady · 2025 — A passive home affordability tracker that shows your buying power on your Home Screen, automatically updated as mortgage rates change.
7. Top Set Calculator · 2025 — Your strength training toolbox in one app. Fast, accurate numbers for 1RM estimation, RPE training, plate loading, and strength scores.
8. Top Set Timer · 2025 — A flexible workout timer for rest intervals, HIIT, and EMOM training. Built for real strength sessions where sets take as long as they take.
9. Top Set Training · 2025 — Proven strength training programs with intelligent auto-regulation that adapts to your performance. 10+ structured programs from beginner to advanced.
10. Turbo Math Games · 2025 — A collection of free browser-based math games for kids featuring arcade-style gameplay, difficulty levels, leaderboards, and a cosmetic shop.
11. Gene2Rx · 2021 — A direct-to-consumer pharmacogenetics interpretation service that turns 23andMe, AncestryDNA, or MyHeritage data into personalized drug-response insights.

Technical Skills