released · 2021
Gene2Rx
A pharmacogenetics report built from your existing 23andMe, AncestryDNA, or MyHeritage data, showing how your genes may affect medication response.
- Built with
- Python, React, PostgreSQL
- Topics
- Pharmacogenomics, Health
Gene2Rx is for people who already have raw DNA data from 23andMe, AncestryDNA, or MyHeritage and want to know what it says about medications. You upload the file you already have, and Gene2Rx produces a report on how your genetics may affect your response to more than 100 drugs. The guidance comes from CPIC guidelines and FDA pharmacogenomic labeling.
How it works
- Download your raw genotype file from 23andMe, AncestryDNA, or MyHeritage and upload it to Gene2Rx.
- The pipeline infers star alleles and functional phenotypes for 23 pharmacogenes.
- You get a report that links your genotypes to predicted drug responses, with citations to the primary sources.
Reports are ready in under a minute.
Coverage
The report covers 23 genes, including ABCG2, ADH1B, CYP2C19, CYP2C9, CYP2D6, SLCO1B1, VKORC1, DPYD, NUDT15, TPMT, and UGT1A1.
It covers 103 drugs across 31 classes. These include antidepressants (SSRIs, SNRIs, and TCAs), antipsychotics, pain medications, statins, antiarrhythmics, anticonvulsants, and chemotherapies. It also covers how you metabolize caffeine, alcohol, THC, and nicotine.
What’s in a report
- A gene summary table with your genotypes, star alleles, and predicted phenotypes, such as normal, intermediate, poor, or rapid metabolizer.
- Drug-specific guidance on which medications may call for a different dose or an alternative.
- Links to the CPIC guideline or FDA label behind each recommendation.
- A clear note that this is not a clinical report. Talk to your doctor before changing any medication.
Pricing
| Report | Medications | Price |
|---|---|---|
| Pain Medication Panel | ~9 pain meds | ~$15 |
| Psychiatric Medication Panel | 23 psych meds | ~$25 |
| Complete Report | All 103 medications | ~$35 |
Free tools
The drug response calculator lets you pick a drug, enter a genotype, and see the matching guidance without uploading a file.
The Gene2Rx blog explains star alleles, CYP2D6, and other pharmacogenetics concepts for non-specialists.
Privacy
Gene2Rx never sells your data. You can ask for it to be deleted completely at any time, and it is stored encrypted. Consumer genotyping arrays also miss some pharmacogenetic variants, so results may be incomplete, and the report says so.
Sources
Every gene-drug relationship comes from either the Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines or the FDA’s Table of Pharmacogenomic Biomarkers in Drug Labeling. Each drug entry links to its source.