journal · 2023
Apolipoprotein C3 induces inflammasome activation only in its delipidated form
Cheng-Chieh Hsu, Baohai Shao, Jenny E. Kanter, Yi He, Tomas Vaisar, Joseph L. Witztum, Janet Snell-Bergeon, Gregory McInnes, Shannon Bruse, Omri Gottesman, Adam E. Mullick, Karin E. Bornfeldt
Nature Immunology
Discovery that apolipoprotein C3 induces inflammasome activation specifically in its delipidated form, revealing new insights into inflammatory mechanisms in cardiovascular disease.
Abstract
Matters arising regarding the lipidation form of plasma APOC3 that induces an alternative NLRP3 activation pathway.
Immunology, Genomics