journal · 2023

Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Cheng-Chieh Hsu, Baohai Shao, Jenny E. Kanter, Yi He, Tomas Vaisar, Joseph L. Witztum, Janet Snell-Bergeon, Gregory McInnes, Shannon Bruse, Omri Gottesman, Adam E. Mullick, Karin E. Bornfeldt

Nature Immunology

A matters-arising reply showing that APOC3 activates the NLRP3 inflammasome only once it has been stripped of lipids.

DOI

Figure from Apolipoprotein C3 induces inflammasome activation only in its delipidated form

Abstract

Matters arising regarding the lipidation form of plasma APOC3 that induces an alternative NLRP3 activation pathway.

Immunology · Genomics